## Asymptotic theory of information-theoretic experimental
design*

Neural Computation 17: 1480-1507.

We discuss an idea for collecting data in a relatively efficient
manner. Our point of view is Bayesian and information-theoretic: on
any given trial, we want to adaptively choose the input in such a way
that the mutual information between the (unknown) state of the system
and the (stochastic) output is maximal, given any prior information
(including data collected on any previous trials). We prove a theorem
that quantifies the effectiveness of this strategy and give a few
illustrative examples comparing the performance of this adaptive
technique to that of the more usual nonadaptive experimental design.
In particular, we calculate the asymptotic efficiency of the
information-maximization strategy and demonstrate that this method
is in a well-defined sense never less efficient --- and is generically
more efficient --- than the nonadaptive strategy. For example, we are
able to explicitly calculate the asymptotic relative efficiency of the
``staircase method'' widely employed in psychophysics research, and to
demonstrate the dependence of this efficiency on the form of the
``psychometric function'' underlying the output responses.

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*A shorter version of this paper was published as: Paninski,
L. (2003). Information-theoretic design of experiments. Advances in
Neural Information Processing 16.