Answers: "Yes, people are right. Caffeine is addictive.", 5 Oct 94, NY Times, p. B9. Journal Article: "Caffeine dependence syndrome: evidence from case histories and experimental evaluations", E.C. Strain et al, 5 Oct 94, JAMA, v. 272, no 3, pp. 1043-1048. 1) Participants were a self-identified group of adults recruited through newspaper notices that sought volunteers who believed they were psychologically or physically dependent on caffeine. They had to be 18 to 50 years of age; have at least a high school diploma or equivalent; have a normal blood pressure, heart rate, and electrocardiogram; have no physical condition contraindicating the consumption of caffeine; were not pregnant, have not used illicit drugs in the past six months; consumed caffeine on a daily basis; and reported problems associated with caffeine use. Subjects were first screened by telephone for suitability, using a questionnaire that reviewed their medical and psychiatric history. Their answers were reviewed by one of the researchers who then determined who were eligible. Those eligible were then requested to come to the research unit for further evaluation. (p.1044-"Methods: Subjects" and "Methods: Study Procedures") 2) 16 out of 27 (59%) caffeine users studied in the first phase were considered addicted. This seems to be a high percentage, but this did not include all caffeine users (including those who did not meet the requirements for the study). So, accounting for all 99 applicants, only 16% are addicted, a fairly low percentage that indicates that caffeine is not a widely addictive drug. Plus, applicants thought that they were addicted to caffeine (were self-identified), so the percentage of all the applicants should be even less than 16%. (p.1044-"Methods: Subjects" and "Methods: Study Procedures") 3) Participants in the double-blind experiments had to be studied in the first phase when they reported to the laboratory on two or more times. signed consent, completed a history questionnaire, underwent a physical examination, filled out one week of food diaries, and went through a standardized psychiatric interview that assessed caffeine dependence. Those who were diagnosed as caffeine dependent and did not have other medical problems were considered for the second phase. (p.1044-"Methods: Study Procedures") 4) In the first phase, the two treatments were caffeine dependent group and the not caffeine dependent, according to their results from their diagnostic interview. In the second phase, these caffeine dependents were given caffeine pills and placebos. (p.1044-"Methods: Study Procedures", p.1045-"Double-Blind Caffeine-Withdrawal Evaluation"-3rd pgrh) 5) Subjects were interviewed by investigators who were blind to the order of the study conditions (ie. order of pills). Subjects were blind in that they were told that they were participating in a study evaluating the effects of food components on mood and behavior. They were instructed to maintain certain dietary restrictions during the 2-day study periods, including food items without caffeine. They also ingested capsules not knowing which contained caffeine or placebo. (p.1044-45-"Methods: Double-Blind Caffeine-Withdrawal Evaluation"-2nd, 3rd, and last pgrhs) 6) Outcomes that were measured were caffeine dependence, various criteria for substance dependence (tolerance symptoms, withdrawal symptoms, persistent desire or unsuccessful efforts to cut down or control use, and any continued use despite knowledge of a persistent or recurrent physical or psychological problem that is likely to have been caused or exacerbated by substance use. (p. 1044-"Methods: Diagnostic Interview, p.1046-47-"Comment"-1st pgrh) 7) The newspaper article gave a very good job in describing the two phases of the study, including an explanation of the criteria used to diagnose substance dependence, description of subjects, and an outline of the events of the study. It even gave further information that includes individual stories of the subjects. It did not, however, mention past psychiatric disorders that the subjects had may alter the way the results are perceived. (p.1047-"Comment"-5th and 6th pgrhs) 8) A possible paragraph would be: "The subjects had few other psychiatric disorders at the same time as when the study was performed, but there were very high rates of past psychiatric disorders, such as nicotine and alcohol dependence. This tendency to have other kinds of substance dependence should be studied to determine whether caffeine dependence is related to alcohol abuse or excessive smoking. A possible idea that should be explored is whether caffeine dependence is a result of quitting other kinds of drugs." (p.1047-"Comment"-5th and 6th pgrhs)